Cognitive

Cerebrolysin

Half-life: 4h Intramuscular or slow intravenous injection/infusion in a clinical setting.

Warnings. Prescription product in approved markets. Rare hypersensitivity reactions; contraindicated in epilepsy and severe renal impairment.

Mechanism

Contains low-molecular-weight neurotrophic peptides that cross the blood-brain barrier and mimic BDNF, GDNF, and CNTF-like activity, promoting neuroplasticity, neurogenesis, and reducing neuronal apoptosis.

Overview

Cerebrolysin is a porcine brain-derived peptide preparation with neurotrophic activity similar to endogenous neurotrophic factors. It is approved in numerous countries for stroke, traumatic brain injury, and dementia. It requires intramuscular or intravenous administration and is dosed by volume rather than mass.

Protocols

Neurotrophic Cycle

Official ADVANCED

Clinical-style weekday dosing over four weeks.

Goal: Neurorecovery and cognition

Step 1 4w

0 mcg · 1×/day · Morning

Dosed by volume, not mass: 5-10mL IV/IM per session, 5 days on / 2 days off, for 4 weeks.