Sexual Health

Melanotan II

Half-life: 1.5h Subcutaneous injection, preferably in the evening to sleep through initial nausea.

Warnings. Research compound. Can darken existing moles and cause new nevi - monitor skin. Nausea and facial flushing common at first; priapism reported at high doses.

Mechanism

Non-selective melanocortin receptor agonist (MC1R-MC5R); MC1R activation increases eumelanin production in melanocytes, while MC4R activation influences sexual function and appetite.

Overview

Melanotan II is a synthetic analog of alpha-MSH that stimulates melanogenesis, producing a tan with minimal UV exposure. It also has pro-sexual effects (it is the parent compound of PT-141) and mild appetite-suppressant properties. It is typically run with a loading phase followed by lower maintenance dosing.

Protocols

Loading + Maintenance Tanning

Official INTERMEDIATE

Low-dose loading to build tolerance, then intermittent maintenance.

Goal: Tanning and libido

Step 1 2w

150 mcg · 1×/day · Evening, before bed

Loading: 50-250mcg daily. Start at 50-100mcg to assess tolerance (nausea is common) and titrate toward 250mcg.

Step 2 8w

375 mcg · 1×/day · Evening

Maintenance: 250-500mcg two to three times per week to sustain the tan. Pair with moderate UV exposure.