Longevity

MOTS-c

Half-life: 1h Subcutaneous injection, ideally in the morning or pre-exercise.

Warnings. Research compound; human clinical data is still emerging.

Mechanism

Activates the AMPK pathway via inhibition of the folate-methionine cycle; translocates to the nucleus under metabolic stress to regulate adaptive gene expression and improve glucose utilization.

Overview

MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome that regulates metabolic homeostasis. It enhances insulin sensitivity, promotes fat oxidation, and has shown exercise-mimetic and lifespan-extending effects in animal studies. Endogenous levels decline with age.

Protocols

Metabolic Optimization Cycle

Official INTERMEDIATE

Intermittent weekly dosing for metabolic and longevity benefits.

Goal: Metabolic health and longevity

Step 1 6w

10 mg · 1×/day

10mg three times per week for 4-6 weeks.