Longevity

NAD+

Half-life: 2h Subcutaneous or intramuscular injection; IV infusions are used clinically but cause flushing/nausea if pushed quickly.

Warnings. Rapid administration commonly causes flushing, chest pressure, and nausea - inject slowly.

Mechanism

Essential co-substrate for sirtuin (SIRT1-7) and PARP enzymes involved in DNA repair and mitochondrial biogenesis; central electron carrier in cellular respiration and ATP production.

Overview

NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme in cellular energy metabolism, DNA repair, and sirtuin activation. Levels decline substantially with age, and replenishment is studied for longevity, energy, and neuroprotection. Injectable NAD+ bypasses the limited oral bioavailability of direct NAD+ supplementation.

Protocols

NAD+ Restoration Protocol

Official INTERMEDIATE

Intermittent dosing to restore cellular NAD+ pools.

Goal: Energy, DNA repair, longevity

Step 1 12w

50 mg · 1×/day

25-100mg per session, 2-3 times per week. Start at 25mg and titrate up as tolerated.