Cognitive

Semax

Half-life: 1h Intranasal spray, typically 1-2 sprays per nostril per dose.

Warnings. Research compound outside Russia/CIS. May cause transient restlessness or insomnia if dosed late in the day.

Mechanism

ACTH(4-10) analog that upregulates BDNF and NGF expression, modulates dopaminergic and serotonergic neurotransmission, and reduces neuroinflammation and oxidative stress.

Overview

Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment developed in Russia as a nootropic and neuroprotective agent. It enhances BDNF expression, improves focus and memory, and is used clinically for stroke recovery and cognitive fatigue. It is administered intranasally for CNS penetration.

Protocols

Nootropic Cycle

Official BEGINNER

Short intranasal cycle for focus and neuroprotection.

Goal: Focus, memory, neuroprotection

Step 1 2.9w

450 mcg · 1×/day · Morning (avoid evening dosing)

300-600mcg per day intranasally for 10-20 days, followed by a break of equal or greater length.