Growth Hormone Secretagogue

Sermorelin

Half-life: 0.2h Subcutaneous injection before bed, at least 90 minutes after the last meal.

Warnings. Generally well tolerated; flushing, dizziness, or injection-site reactions possible.

Mechanism

Binds GHRH receptors on pituitary somatotrophs to stimulate endogenous GH secretion while preserving somatostatin negative-feedback regulation, maintaining physiological pulsatility.

Overview

Sermorelin is a GHRH(1-29) analog that stimulates natural, pulsatile growth hormone release from the pituitary. It was previously FDA-approved for pediatric GH deficiency and is widely used off-label for adult GH optimization. Users typically report improved sleep, recovery, and body composition.

Protocols

Nightly GH Optimization

Official BEGINNER

Single pre-bed dose to amplify the nocturnal GH pulse.

Goal: Sleep, recovery, anti-aging

Step 1 12w

400 mcg · 1×/day · Before bed, on an empty stomach

300-500mcg before bed. Typical evaluation period is 90 days via IGF-1 labs.