Growth Hormone Secretagogue

Ipamorelin

Half-life: 2h Subcutaneous injection on an empty stomach; avoid food 30 min before and after dosing.

Warnings. Research compound. May cause transient hunger, water retention, or numbness/tingling at high doses.

Mechanism

Selective agonist of the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs, triggering pulsatile GH release without significant ACTH or prolactin stimulation.

Overview

Ipamorelin is a highly selective growth hormone secretagogue and ghrelin mimetic that stimulates GH release without significantly raising cortisol or prolactin. It is considered one of the cleanest GHRPs with minimal side effects. Frequently combined with CJC-1295 (no DAC) for synergy.

Protocols

Standard GHRP Protocol

Official INTERMEDIATE

Pulsatile dosing with weekly breaks, alone or stacked with a GHRH analog.

Goal: Recovery, body composition, sleep

Step 1 12w

200 mcg · 3×/day · Morning fasted, post-workout, and/or before bed

100-300mcg per dose, 1-3x/day. Start at 100mcg before bed and titrate up. 5 days on, 2 days off.

Stacks well with

CJC-1295 (no DAC)

Enhanced GH pulse when stacked